INDICATION

ABECMA (idecabtagene vicleucel) is a B-cell maturation antigen (BCMA)-directed genetically modified autologous T cell immunotherapy indicated for the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody.

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Outcomes Are Poor in Triple Class–Exposed* RRMM Patients1,2

Although advancements in the treatment of RRMM have transformed outcomes, deep and durable responses remain difficult to achieve after patients have received an IMiD® agent, a PI, and an anti-CD38 antibody.1-3

When patients relapse, their disease becomes increasingly nonresponsive to the 3 main classes of treatments,1,4 resulting in:

  • Shorter remissions between treatments4,5
  • Rising burden of continuous administrations6,7
  • Decreased quality of life6,7
Course of Disease Graphic

No standard of care exists for triple class–exposed* RRMM, and several studies have demonstrated poor outcomes in these patients4

Outcomes after
triple-class exposure*

26%-32%

ORR1,2,9,10

2%-3%

≥CR9,10

3-5 months

mPFS1,2,9-11

Novel mechanisms of action are needed in the management of RRMM1

After receiving multiple lines of therapy, patients’ T cell populations can become compromised, with fewer healthy T cells present. This can lead to12-14:

  • Continued immune dysfunction
  • Uncontrolled residual disease

Triple class–exposed* patients are in need of a novel treatment that:

  • Can deliver deep responses with long durations of response5
  • Alleviates the need for repeated administration15,16
  • Increases quality of life6,7

Harnessing the power of the immune system early, while these immune cells are healthy, represents an important window of opportunity12

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Although treatment of RRMM is evolving, an unmet need remains—especially for triple class–exposed* patients.1-3

See more data for
triple class–exposed* patients

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treatment center near you

CR=complete response; mPFS=median progression-free survival; ORR=overall response rate; PI=proteasome inhibitor; RRMM=relapsed/refractory multiple myeloma.

Received an IMiD® agent, a PI, and an anti-CD38 antibody.